Berberine is herb known for Treatment of Prediabetes and Type 2 Diabetes

berberine

Berberine is an alkaloid extracted from various plants used in traditional Chinese medicine. It’s primarily used to reduce insulin resistance and improve biomarkers of type II diabetes such as fasting glucose and glycated hemoglobin. Berberine can activate an enzyme called Adenosine Monophosphate-Activated Protein Kinase (AMPK) while inhibiting Protein-Tyrosine Phosphatase 1B (PTP1B), thus increasing insulin sensitivity. Other possible mechanisms of action include protecting and β-cells, regulating hepatic gluconeogenesis, and reducing inflammatory cytokine signaling. Berberine possesses all the other standard phytochemical properties of ‘antioxidant, anti inflammatory, cognitive protective, etc.’ properties. Berberine’s potential lies in with glucose and fatty acid metabolism (which is, inherently, a huge deal) as well as intestinal health.

TRADITIONAL HEALTH BENEFITS OF berberine

Reduce insulin resistance and improve biomarkers of type II diabetes.

WHAT IS berberine USED FOR?

Human and animal research suggests that 1500mg of berberine, taken in three doses of 500mg each, is equally effective as taking 1500mg of metformin or 4mg glibenclamide, two pharmaceuticals for treating type II diabetes. Effectiveness was measured by how well the drugs reduced biomarkers of type II diabetes.

Some evidence suggests that it can reduce LDL-cholesterol and triglycerides in type II diabetics, and possibly lead to a small increase in HDL-cholesterol. Berberine also appears to have historical usage as 'Herbal Imodium' and can reduce the frequency of diarrhea.

Product Featuring berberine

Side-effects and drawbacks?

Gastrointestinal upset can occur when high doses are used, and due to its ability to reduce blood sugar, it may increase the risk for hypoglycemia in high doses, though this isn't a common occurrence.

Is Berberine safe to take?

Tentatively, yes, but a doctor's guidance is highly recommended. Berberine has been the subject of much research and seems to be potent like many pharmaceuticals.

How to take?

The standard dose of berberine is 900-2,000mg a day, divided into three to four doses. Berberine should be taken with a meal, or shortly after, to take advantage of the blood glucose and lipid spike associated with eating. Too much berberine at once can result in stomach upset, cramping, and diarrhea.

Disclaimer

This information in our Herbal Reference Guide is intended only as a general reference for further exploration, and is not a replacement for professional health advice. Accordingly, this information should be used only under the supervision of a qualified health practitioner.